Galanthamine-O-methyl-d3

Galanthamine-O-methyl-d3

• CAS Number: 1279031-09-2
• UNSPSC Description: Galanthamine-O-methyl-d3 is the deuterium labeled Galanthamine. Galanthamine is a potent acetylcholinesterase (AChE) inhibitor with an IC50 of 500 nM.
• Target Antigen: Apoptosis; Cholinesterase (ChE); Isotope-Labeled Compounds
• Type: Isotope-Labeled Compounds
• Related Pathways: Apoptosis;Neuronal Signaling;Others
• Field of Research: Neurological Disease
• Solubility: 10 mM in DMSO
• Smiles: O(C([2H])([2H])[2H])C1=C2C=3[C@]4([C@@](O2)(C[C@@H](O)C=C4)[H])CCN(C)CC3C=C1
• Molecular Weight: 290.37
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Kita Y, et al. Galantamine increases hippocampal insulin-like growth factor 2 expression via α7 nicotinic acetylcholine receptors in mice. Psychopharmacology (Berl). 2013 Feb;225(3):543-51.|[3]Melanie-Jayne R. Howes, et al. Acetylcholinesterase inhibitors of natural origin. International Journal of Research in Pharmaceutical and Biomedical Sciences 3(SI 1):67-86.|[4]Kuryatov A, et al. Roles of accessory subunits in alpha4beta2(*) nicotinic receptors. Mol Pharmacol. 2008 Jul;74(1):132-43.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported