CCDC45 Polyclonal Antibody

CAT: 0749-ABP50888-01Size: 30 µLDry Ice: NoHazardous: No
CAT#:0749-ABP50888-01Size:30 µL
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Background
The coiled-coil domain is a structural motif found in proteins that are involved in a diverse array of biological functions such as the regulation of gene expression, cell division, membrane fusion and drug extrusion and delivery. CCDC45 (coiled-coil domain containing 45) is a 821 amino acid protein encoded by a gene that maps to human chromosome 17q23.3. Chromosome 17 comprises over 2.5% of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes.
Description
Rabbit Anti-CCDC45 Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
CEP95; CCDC45; CEP45; Centrosomal protein of 95 kDa; Coiled-coil domain-containing protein 45
Gene ID
90799
Accession Number
Q96GE4
Reactivity
Human, Mouse, Rat
Immunogen
Synthesized peptide derived from the Internal region of human CCDC45 at AA range: 560-640
Clonality
Polyclonal
Tag
Centrosomal protein of 95 kDa
Applications
WB, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
95kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
CCDC45 Polyclonal Antibody detects endogenous levels of CCDC45 protein.
Observed Molecular Weight
95
Formulation
Liquid solution
Buffer pH
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000; ELISA 1:40000; Not yet tested in other applications.
Other Product Names
CEP95; CCDC45; CEP45; Centrosomal protein of 95 kDa; Coiled-coil domain-containing protein 45
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/Q96GE4
Isotype
Rabbit IgG

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