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CAGE-1 Polyclonal Antibody

CAT: 0749-ABP50829-01Size: 30 µLDry Ice: NoHazardous: No
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CAT#:0749-ABP50829-01Size:30 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
CAGE (cancer-associated gene protein), also known as DEAD box protien 53 (DDX53) or DEAD box protein CAGE, belongs to the DEAD box helicase family. It contains one helicase ATP-binding domain, one helicase C-terminal domain and one KH domain. CAGE localizes to the nucleus and, in normal adult tissues, is exclusively expressed in testis but it has also been found in a wide variety of cancer tissues and cell lines. Overexpression of CAGE leads to the activation of FAK, ERK and p38 MAPK along with a reduction in reactive oxygen species (ROS) . It is also responsible for inducing catalase activity and therefore enhancing cell motility. This suggests that CAGE may enhance the migration of cancer cells. In addition, hypomethylation of the CAGE promoter region is associated with tumor progression and may serve as a valuable marker in cancer diagnosis.
Description
Rabbit Anti-CAGE-1 Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
CAGE1; CTAG3; Cancer-associated gene 1 protein; CAGE-1; Cancer/testis antigen 3; CT3
Gene ID
285782
Accession Number
Q8TC20
Reactivity
Human, Rat, Mouse
Immunogen
Synthesized peptide derived from the C-terminal region of human CAGE-1 at AA range: 680-760
Clonality
Polyclonal
Tag
Cancer-associated gene 1 protein
Applications
WB, IHC, IF, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
90kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
CAGE-1 Polyclonal Antibody detects endogenous levels of CAGE-1 protein.
Observed Molecular Weight
90
Formulation
Liquid solution
Buffer pH
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:40000; IF 1:50-200
Other Product Names
CAGE1; CTAG3; Cancer-associated gene 1 protein; CAGE-1; Cancer/testis antigen 3; CT3
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/Q8TC20
Isotype
Rabbit IgG

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