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Rb (phospho Ser807) Polyclonal Antibody

CAT: 0749-ABP50402-01Size: 30 µLDry Ice: NoHazardous: No
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CAT#:0749-ABP50402-01Size:30 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
RB transcriptional corepressor 1 encoded by RB1 is a negative regulator of the cell cycle and was the first tumor suppressor gene found. RB transcriptional corepressor 1 also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in RB1 are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.
Description
Rabbit Anti-Rb (phospho Ser807) Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
RB1; Retinoblastoma-associated protein; p105-Rb; pRb; Rb; pp110
Gene ID
5925
Accession Number
P06400
Reactivity
Human, Mouse, Rat
Immunogen
Synthesized peptide derived from human Rb around the phosphorylation site of S807
Clonality
Polyclonal
Tag
Retinoblastoma-associated protein
Applications
WB, IHC, IF, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
106kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
Phospho-Rb (S807) Polyclonal Antibody detects endogenous levels of Rb protein only when phosphorylated at S807.
Observed Molecular Weight
106
Formulation
Liquid solution
Buffer pH
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000; IF 1:50-200
Other Product Names
RB1; Retinoblastoma-associated protein; p105-Rb; pRb; Rb; pp110
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/P06400
Isotype
Rabbit IgG

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