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Vps34-IN-2

CAT: 0804-HY-12473-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-12473-01Size:1 mg
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Description
Vps34-IN-2 is a novel, potent and selective inhibitor of Vps34 with IC50s of 2 and 82 nM on the Vps34 enzymatic assay and the GFP-FYVE cellular assay, respectively[1]. Vps34-IN-2 shows antiviral activity against SARS-CoV-2 (IC50 of 3.1 μM), HCoV-229E (IC50 of 0.7 μM) and HCoV-OC43[2].
CAS Number
1523404-29-6
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
PI3K; SARS-CoV
Type
Reference compound
Related Pathways
Anti-infection; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Vps34-IN-2.html
Purity
99.81
Solubility
DMSO : ≥ 50 mg/mL|Ethanol : 50 mg/mL (ultrasonic)
Smiles
O=C1C=C(N2[C@H](C)COCC2)N=C3N(CC(C(C)C)=O)[C@H](C(F)(F)F)CCN31
Molecular Formula
C18H25F3N4O3
Molecular Weight
402.41
Precautions
H302, H315, H319, H335
References & Citations
[1]Pasquier B, et al. Discovery of (2S) -8-[ (3R) -3-methylmorpholin-4-yl]-1- (3-methyl-2-oxobutyl) -2- (trifluoromethyl) -3,4-dihydro-2H-pyrimido[1,2-a]pyrimidin-6-one: a novel potent and selective inhibitor of Vps34 for the treatment of solid tumors. J Med Chem. 2015 Jan 8;58 (1) :376-400.|[2]Jim Baggen, et al. Genome-wide CRISPR screening identifies TMEM106B as a proviral host factor for SARS-CoV-2. Nat Genet. 2021 Mar 8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Vps34

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Alternative Products

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A16933-25Vps34-IN-2 25mg
A16933-2Vps34-IN-2 2mg
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A16933-100Vps34-IN-2 100mg
A16933-10Vps34-IN-2 10mg
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