Products for Research Use Only
RegisterLogin

ERK1/2 inhibitor 9

CAT: 0804-HY-153738-01Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-153738-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
ERK1/2 inhibitor 9 (Probe 1) is a covalent ERK1/2 inhibitor. ERK1/2 inhibitor 9 shows sub-micromolar activity in cells (A375 GI50=0.47 μM) . ERK1/2 inhibitor 9 causes the downregulation of phospho-ERK1/2. ERK1/2 inhibitor 9 tagged trans-cyclo-octene (TCO) and Tz-Thalidomide (tetrazine tagged Thalidomide) can form the corresponding ERK-CLIPTAC to elicit degradation of ERK1/2[1].
CAS Number
2169302-75-2
UNSPSC
12352005
Target
ERK
Type
Reference compound
Related Pathways
MAPK/ERK Pathway; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/erk1-2-inhibitor-9.html
Purity
95.91
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(NCCC#CC1=NC=CC(NC2=NC=C(C(NC3=C(NC(C=C)=O)C=CC=C3)=N2)Cl)=C1)OC4CC/C=C\CCC4
Molecular Formula
C31H32ClN7O3
Molecular Weight
586.08
References & Citations
[1]Honorine Lebraud, et al. Protein Degradation by In-Cell Self-Assembly of Proteolysis Targeting Chimeras. ACS Cent Sci. 2016 Dec 28;2 (12) :927-934.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ERK1; ERK2

Related Products

CatalogName
HY-145027ERK1/2 inhibitor 5
HY-W838814ERK1/2 inhibitor 12
HY-145025ERK1/2 inhibitor 3
HY-142437ERK1/2 inhibitor 8
HY-112287-01ERK1/2 inhibitor 1
HY-145028ERK1/2 inhibitor 6
HY-173060ERK1/2 inhibitor 13
HY-168171ERK1/2 inhibitor 11
HY-145026ERK1/2 inhibitor 4
HY-142433-01ERK1/2 inhibitor 7

Alternative Products

CatalogName
GTR19166157-01ERK1/2 inhibitor 2
VID71990-01Erk1/2 inhibitor 1
T78190-01ERK1/2 inhibitor 9
MBS5816338ERK1/2 Inhibitor 4
GTR19221292-01ERK1/2 inhibitor 3
GTR19249589-01ERK1/2 inhibitor 13
T63331-01ERK1/2 inhibitor 8
MBS5806808ERK1/2 Inhibitor 6
MBS5806816ERK1/2 Inhibitor 5
MBS5805611ERK1/2 Inhibitor 7

Popular Products