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ERK1/2 inhibitor 13

CAT: 0804-HY-173060Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-173060Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ERK1/2 inhibitor 13 (Compound 21y) is the orally active inhibitor for ERK that inhibits ERK1 and ERK2 with IC50 of 91.71 nM and 97.87 nM. ERK1/2 inhibitor 13 inhibits the proliferation of MCF-7, 4T1, MDA-MB-468, and HCC1970 (IC50 of 0.67, 2.76, 2.15 and 1.68 μM), inhibits the cancer cell migration, induces apoptosis and autophagy in MCF-7. ERK1/2 inhibitor 13 exhibits antitumor and anti-metastatic effect in 4T1 xenograft mouse model[1].
CAS Number
3093367-23-5
UNSPSC
12352005
Target
Apoptosis; Autophagy; ERK
Related Pathways
Apoptosis; Autophagy; MAPK/ERK Pathway; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
FC(F)(C1=CC(NC(N[C@@H](CC2=CC=CC=C2)CN3C=[N+](CC4=CC=CC5=C4C=CC=C5)C6=C3C=CC=C6)=O)=CC(C(F)(F)F)=C1)F.[Br-]
Molecular Formula
C36H29BrF6N4O
Molecular Weight
727.54
References & Citations
[1]Wang M, et al., Discovery of Novel Aromatic Urea-Imidazole Salt Derivatives for Cancer Therapy via Targeting ERK1/2. J Med Chem. 2025 Feb 27;68 (4) :4101-4132.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ERK1; ERK2

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