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PHLP1 rabbit pAb

CAT: 0855-ES11925-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES11925-01Size:50 µL
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Background
PH domain and leucine rich repeat protein phosphatase 1 (PHLPP1) Homo sapiens This gene encodes a member of the serine/threonine phosphatase family. The encoded protein promotes apoptosis by dephosphorylating and inactivating the serine/threonine kinase Akt, and functions as a tumor suppressor in multiple types of cancer. Increased expression of this gene may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated insulin signaling. [provided by RefSeq, Dec 2011]
Description
PH domain and leucine rich repeat protein phosphatase 1 (PHLPP1) Homo sapiens This gene encodes a member of the serine/threonine phosphatase family. The encoded protein promotes apoptosis by dephosphorylating and inactivating the serine/threonine kinase Akt, and functions as a tumor suppressor in multiple types of cancer. Increased expression of this gene may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated insulin signaling. [provided by RefSeq, Dec 2011],
UniProt
O60346
Swiss Prot
O60346
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized peptide derived from part region of human protein
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Molecular Weight
188kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
188kD
Fragment
IgG
Subcellular Location
Cytoplasm. Membrane; Peripheral membrane protein. Nucleus. In colorectal cancer tissue, expression is concentrated at the lateral membrane of epithelial cells.; [Isoform 2]: Cell membrane .
Gene ID (Human)
23239

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