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RBP1 rabbit pAb

CAT: 0855-ES11888-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES11888-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
RALBP1 plays a role in receptor-mediated endocytosis and is a downstream effector of the small GTP-binding protein RAL (see RALA; MIM 179550) . Small G proteins, such as RAL, have GDP-bound inactive and GTP-bound active forms, which shift from the inactive to the active state through the action of RALGDS (MIM 601619), which in turn is activated by RAS (see HRAS; MIM 190020) (summary by Feig, 2003 [PubMed 12888294]) .[supplied by OMIM, Nov 2010]
Description
RALBP1 plays a role in receptor-mediated endocytosis and is a downstream effector of the small GTP-binding protein RAL (see RALA; MIM 179550). Small G proteins, such as RAL, have GDP-bound inactive and GTP-bound active forms, which shift from the inactive to the active state through the action of RALGDS (MIM 601619), which in turn is activated by RAS (see HRAS; MIM 190020) (summary by Feig, 2003 [PubMed 12888294]). [supplied by OMIM, Nov 2010],
UniProt
Q15311
Swiss Prot
Q15311
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized peptide derived from part region of human protein
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Molecular Weight
72kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
72kD
Fragment
IgG
Subcellular Location
Cell membrane ; Peripheral membrane protein . Cytoplasm, cytosol . Cytoplasm, cytoskeleton, spindle pole . Nucleus . Mitochondrion . Cytosolic protein that transiently associates with the mitotic spindle poles in early prophase, and dissociates from them after completion of mitosis (By similarity) . Targeted to the plasma membrane through its interaction with RALB, directed by FGF signaling. Docking on the membrane is required to transduce the Ral signal (By similarity) . Recruited by RALA to the mitochondrion during mitosis where it regulates mitochondrial fission (PubMed:21822277) . Nuclear localization is cell cycle dependent while membrane localization is seen in adherent cells (PubMed:22319010) . The region involved in membrane association could form transmembrane domains and expose a par
Gene ID (Human)
10928

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