Products for Research Use Only
RegisterLogin

FILA rabbit pAb

CAT: 0855-ES11828-01Size: 50 µLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0855-ES11828-01Size:50 µL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
The protein encoded by this gene is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Mutations in this gene are associated with ichthyosis vulgaris.[provided by RefSeq, Dec 2009]
Description
The protein encoded by this gene is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Mutations in this gene are associated with ichthyosis vulgaris. [provided by RefSeq, Dec 2009],
UniProt
P20930
Swiss Prot
P20930
Reactivity
Human; Rat; Mouse
Immunogen
Synthesized peptide derived from part region of human protein
Clonality
Polyclonal
Source
Rabbit
Applications
IHC; IF
Concentration
1 mg/ml
Dilution
IHC-p 1:50-300
Molecular Weight
446kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
446kD
Fragment
IgG
Subcellular Location
Cytoplasmic granule . In the stratum granulosum of the epidermis, localized within keratohyalin granules (PubMed:1429717) . In granular keratinocytes and in lower corneocytes, colocalizes with calpain-1/CAPN1 (PubMed:21531719) . .
Gene ID (Human)
2312

UniProtKB · P20930

Filaggrin

FILA_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P20930
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
FLG
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q01720, Q5T583, Q9UC71
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Ligand

CalciumMetal-binding

PTM

CitrullinationPhosphoprotein

Domain

Coiled coilRepeat

Molecular function

Developmental protein

Disease

Ichthyosis

Related Products

CatalogName
ES16461-01FILA2 rabbit pAb
ES4666-01RAB3IP rabbit pAb
ES20751-01Gab1 Rabbit rabbit pAb
ES20703-01JAK2 Rabbit rabbit pAb
ES20758-01ERK1 Rabbit rabbit pAb
ES20830-01ATG14L Rabbit rabbit pAb
ES20829-01ATG4a Rabbit rabbit pAb
ES20658-01NM23A Rabbit rabbit pAb
ES20826-01ATG5 Rabbit rabbit pAb
ES20827-01ATG4c Rabbit rabbit pAb

Alternative Products

CatalogName
APRab10985-01FILA Rabbit Polyclonal Antibody
PAV1450Rabbit Anti-FILA/FLG Polyclonal Antibody
536329-01FILA discontinued
C43788-01FILA Antibody
UB-GEN-7571FILA Polyclonal Antibody
STJ192986Anti-FILA antibody
E102881Mouse FILA ELISA Kit
E102880Human FILA ELISA Kit
WP3259-01U-Blot® FILA Polyclonal Antibody
316152-01Filaggrin (Epidermal Filaggrin, FILA, Filaggrin Precursor, Profilaggrin, bFGF-R-1, FGFBR, FLG, FLT2, FGFR1, FLG, FLT-2, Fms-like Tyrosine Kinase 2, Proto-oncogene c-Fgr)

Popular Products