PABP1 rabbit pAb

CAT: 0855-ES11752-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0855-ES11752-01Size:50 µL
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Background
This gene encodes a poly (A) binding protein. The protein shuttles between the nucleus and cytoplasm and binds to the 3' poly (A) tail of eukaryotic messenger RNAs via RNA-recognition motifs. The binding of this protein to poly (A) promotes ribosome recruitment and translation initiation; it is also required for poly (A) shortening which is the first step in mRNA decay. The gene is part of a small gene family including three protein-coding genes and several pseudogenes.[provided by RefSeq, Aug 2010]
Description
This gene encodes a poly (A) binding protein. The protein shuttles between the nucleus and cytoplasm and binds to the 3' poly (A) tail of eukaryotic messenger RNAs via RNA-recognition motifs. The binding of this protein to poly (A) promotes ribosome recruitment and translation initiation; it is also required for poly (A) shortening which is the first step in mRNA decay. The gene is part of a small gene family including three protein-coding genes and several pseudogenes. [provided by RefSeq, Aug 2010],
UniProt
P11940
Swiss Prot
P11940
Reactivity
Human; Rat; Mouse
Immunogen
Synthesized peptide derived from part region of human protein AA range: 212-262
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Molecular Weight
69kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
69kD
Fragment
IgG
Subcellular Location
Cytoplasm . Cytoplasm, Stress granule . Nucleus . Cell projection, lamellipodium . Localized in cytoplasmic mRNP granules containing untranslated mRNAs (PubMed:17289661) . Shuttles between the cytoplasm and the nucleus (PubMed:9582337) . During stress and in the absence of DDX3X, localizes to the nucleus (PubMed:21883093) . At the leading edge of migrating fibroblasts, colocalizes with DDX3X (PubMed:28733330) . Relocalizes to cytoplasmic stress granules upon cellular stress where it colocalizes with ENDOV (PubMed:27573237) . In case of HRSV infection, localizes in cytoplasmic inclusion bodies substructures called inclusion bodies associated granules (IBAGs) (PubMed:31649314) . .
Gene ID (Human)
26986

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