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MRGX2 rabbit pAb

CAT: 0855-ES11657-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES11657-01Size:50 µL
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Background
Function:Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Cortistatin-14 seems to be a high potency ligand at this receptor. Cortistatin has several biological functions including roles in sleep regulation locomotor activity, and cortical function. In receptor-expressing cells, cortistatin-stimulated increases in intracellular Ca (2+) but had no effect on basal or forskolin-stimulated cAMP levels, suggesting that this receptor is G (q) -coupled., similarity:Belongs to the G-protein coupled receptor 1 family. Mas subfamily., tissue specificity:Has a limited expression profile, both peripheral and within the central nervous system, with highest levels in dorsal root ganglion.
Description
Function: Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Cortistatin-14 seems to be a high potency ligand at this receptor. Cortistatin has several biological functions including roles in sleep regulation locomotor activity, and cortical function. In receptor-expressing cells, cortistatin-stimulated increases in intracellular Ca (2+) but had no effect on basal or forskolin-stimulated cAMP levels, suggesting that this receptor is G (q)-coupled. similarity: Belongs to the G-protein coupled receptor 1 family. Mas subfamily. tissue specificity: Has a limited expression profile, both peripheral and within the central nervous system, with highest levels in dorsal root ganglion.
UniProt
Q96LB1
Swiss Prot
Q96LB1
Reactivity
Human; Mouse
Immunogen
Synthesized peptide derived from human protein . at AA range: 250-330
Target
MRGX2
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Buffer
-20°C/1 year
Molecular Weight
36kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
36kD
Fragment
IgG
Subcellular Location
Cell membrane; Multi-pass membrane protein .
Gene ID (Human)
117194

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