FPR2 rabbit pAb

• Background:

  Function:Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4) ., similarity:Belongs to the G-protein coupled receptor 1 family., tissue specificity:Expressed abundantly in the lung and neutrophils. Also found in the spleen and testis.

• Description:

  Function: Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4). similarity: Belongs to the G-protein coupled receptor 1 family. tissue specificity: Expressed abundantly in the lung and neutrophils. Also found in the spleen and testis.

• Gene ID:

  2358

• UniProt:

  P25090

• Cellular Locus:

  Cell membrane ; Multi-pass membrane protein. Associates with Amyloid-beta protein 42, product of APP, at the cell surface and the complex is then rapidly internalized (PubMed:11689470). Also internalized in the presence of humanin (PubMed:15465011)..

• Host:

  Rabbit

• Species Reactivity:

  Human, Rat, Mouse, Swine

• Reactivity:

  Human; Rat; Mouse; ; Swine

• Immunogen:

  Synthesized peptide derived from human protein . at AA range: 130-210

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Source:

  Rabbit

• Applications:

  WB, ELISA

• Validated Applications:

  WB, ELISA

• Stability:

  -20°C/1 year

• Concentration:

  1 mg/mL

• Dilution:

  WB 1:500-2000 ELISA 1:5000-20000

• Molecular Weight:

  38kD

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

• Observed Molecular Weight:

  38 kD

• Subcellular Location:

  Cell membrane ; Multi-pass membrane protein. Associates with Amyloid-beta protein 42, product of APP, at the cell surface and the complex is then rapidly internalized (PubMed:11689470) . Also internalized in the presence of humanin (PubMed:15465011) . .

• Gene ID (Human):

  2358

• SwissProt (Human):

  P25090