FPR2 rabbit pAb

CAT: 0855-ES11464-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0855-ES11464-01Size:50 µL
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Background
Function:Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4) ., similarity:Belongs to the G-protein coupled receptor 1 family., tissue specificity:Expressed abundantly in the lung and neutrophils. Also found in the spleen and testis.
Description
Function: Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4). similarity: Belongs to the G-protein coupled receptor 1 family. tissue specificity: Expressed abundantly in the lung and neutrophils. Also found in the spleen and testis.
UniProt
P25090
Swiss Prot
P25090
Reactivity
Human; Rat; Mouse; ; Swine
Immunogen
Synthesized peptide derived from human protein . at AA range: 130-210
Target
FPR2
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Buffer
-20°C/1 year
Molecular Weight
38kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
38kD
Fragment
IgG
Subcellular Location
Cell membrane ; Multi-pass membrane protein. Associates with Amyloid-beta protein 42, product of APP, at the cell surface and the complex is then rapidly internalized (PubMed:11689470) . Also internalized in the presence of humanin (PubMed:15465011) . .
Gene ID (Human)
2358

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