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FURIN rabbit pAb

CAT: 0855-ES11332-01Size: 50 µLDry Ice: NoHazardous: No
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Background
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. It encodes a type 1 membrane bound protease that is expressed in many tissues, including neuroendocrine, liver, gut, and brain. The encoded protein undergoes an initial autocatalytic processing event in the ER and then sorts to the trans-Golgi network through endosomes where a second autocatalytic event takes place and the catalytic activity is acquired. The product of this gene is one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. Some of its substrates include proparathyroid hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix m
Description
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. It encodes a type 1 membrane bound protease that is expressed in many tissues, including neuroendocrine, liver, gut, and brain. The encoded protein undergoes an initial autocatalytic processing event in the ER and then sorts to the trans-Golgi network through endosomes where a second autocatalytic event takes place and the catalytic activity is acquired. The product of this gene is one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. Some of its substrates include proparathyroid hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix m
UniProt
P09958
Swiss Prot
P09958
Reactivity
Human; Rat; Mouse
Immunogen
Synthesized peptide derived from human protein . at AA range: 340-420
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Molecular Weight
87kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
87kD
Fragment
IgG
Subcellular Location
Golgi apparatus, trans-Golgi network membrane ; Single-pass type I membrane protein . Cell membrane ; Single-pass type I membrane protein . Secreted . Endosome membrane ; Single-pass type I membrane protein . Shuttles between the trans-Golgi network and the cell surface (PubMed:9412467, PubMed:11799113) . Propeptide cleavage is a prerequisite for exit of furin molecules out of the endoplasmic reticulum (ER) . A second cleavage within the propeptide occurs in the trans Golgi network (TGN), followed by the release of the propeptide and the activation of furin (PubMed:11799113) . .
Gene ID (Human)
5045

UniProtKB · P09958

Furin

FURIN_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P09958
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
FURIN
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.4.21.75
Processing
Precursor
Secondary accessions
Q14336, Q6LBS3, Q9UCZ5
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

Autocatalytic cleavageCleavage on pair of basic residuesDisulfide bondGlycoproteinPhosphoproteinZymogen

Ligand

CalciumMetal-binding

Cellular component

Cell membraneEndosomeGolgi apparatusMembraneSecreted

Molecular function

Heparin-bindingHydrolaseProteaseSerine protease

Biological process

Host-virus interaction

Domain

RepeatSignalTransmembraneTransmembrane helix

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