TPP1 rabbit pAb

• Background:

  This gene encodes a member of the sedolisin family of serine proteases. The protease functions in the lysosome to cleave N-terminal tripeptides from substrates, and has weaker endopeptidase activity. It is synthesized as a catalytically-inactive enzyme which is activated and auto-proteolyzed upon acidification. Mutations in this gene result in late-infantile neuronal ceroid lipofuscinosis, which is associated with the failure to degrade specific neuropeptides and a subunit of ATP synthase in the lysosome. [provided by RefSeq, Jul 2008]

• Description:

  This gene encodes a member of the sedolisin family of serine proteases. The protease functions in the lysosome to cleave N-terminal tripeptides from substrates, and has weaker endopeptidase activity. It is synthesized as a catalytically-inactive enzyme which is activated and auto-proteolyzed upon acidification. Mutations in this gene result in late-infantile neuronal ceroid lipofuscinosis, which is associated with the failure to degrade specific neuropeptides and a subunit of ATP synthase in the lysosome. [provided by RefSeq, Jul 2008],

• UniProt:

  O14773

• Swiss Prot:

  O14773

• Reactivity:

  Human; Rat; Mouse

• Immunogen:

  Synthesized peptide derived from human protein . at AA range: 10-90

• Clonality:

  Polyclonal

• Source:

  Rabbit

• Applications:

  WB; ELISA

• Concentration:

  1 mg/ml

• Dilution:

  WB 1:500-2000 ELISA 1:5000-20000

• Molecular Weight:

  61kD

• Storage Conditions:

  -20°C/1 year

• Observed Molecular Weight:

  61kD

• Fragment:

  IgG

• Subcellular Location:

  Lysosome . Melanosome . Identified by mass spectrometry in melanosome fractions from stage I to stage IV. .

• Gene ID (Human):

  1200