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TP4A2 rabbit pAb

CAT: 0855-ES11052-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES11052-01Size:50 µL
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Background
Protein tyrosine phosphatase type IVA, member 2 (PTP4A2) Homo sapiens The protein encoded by this gene belongs to a small class of the protein tyrosine phosphatase (PTP) family. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. PTPs in this class contain a protein tyrosine phosphatase catalytic domain and a characteristic C-terminal prenylation motif. This PTP has been shown to primarily associate with plasmic and endosomal membrane through its C-terminal prenylation. This PTP was found to interact with the beta-subunit of Rab geranylgeranyltransferase II (beta GGT II), and thus may function as a regulator of GGT II activity. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which suggested its role in tumorigenesis. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 11, 12 and 17. [provided by RefSeq, Aug 2010]
Description
Protein tyrosine phosphatase type IVA, member 2 (PTP4A2) Homo sapiens The protein encoded by this gene belongs to a small class of the protein tyrosine phosphatase (PTP) family. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. PTPs in this class contain a protein tyrosine phosphatase catalytic domain and a characteristic C-terminal prenylation motif. This PTP has been shown to primarily associate with plasmic and endosomal membrane through its C-terminal prenylation. This PTP was found to interact with the beta-subunit of Rab geranylgeranyltransferase II (beta GGT II), and thus may function as a regulator of GGT II activity. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which suggested its role in tumorigenesis. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 11, 12 and 17. [provided by RefSeq, Aug 2010],
UniProt
Q12974
Swiss Prot
Q12974
Reactivity
Human; Rat; Mouse
Immunogen
Synthesized peptide derived from part region of human protein
Target
TP4A2
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Buffer
-20°C/1 year
Molecular Weight
18kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
18kD
Fragment
IgG
Subcellular Location
Cell membrane. Early endosome. Cytoplasm.
Gene ID (Human)
8073

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