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FHL2 rabbit pAb

CAT: 0855-ES11019-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES11019-01Size:50 µL
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Background
This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. This protein is thought to have a role in the assembly of extracellular membranes. Also, this gene is down-regulated during transformation of normal myoblasts to rhabdomyosarcoma cells and the encoded protein may function as a link between presenilin-2 and an intracellular signaling pathway. Multiple alternatively spliced variants encoding different isoforms have been identified. [provided by RefSeq, Jan 2016]
Description
This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. This protein is thought to have a role in the assembly of extracellular membranes. Also, this gene is down-regulated during transformation of normal myoblasts to rhabdomyosarcoma cells and the encoded protein may function as a link between presenilin-2 and an intracellular signaling pathway. Multiple alternatively spliced variants encoding different isoforms have been identified. [provided by RefSeq, Jan 2016],
UniProt
Q14192
Swiss Prot
Q14192
Reactivity
Human; Rat; Mouse
Immunogen
Synthesized peptide derived from part region of human protein
Target
FHL2
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Buffer
-20°C/1 year
Molecular Weight
30kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
30kD
Fragment
IgG
Subcellular Location
Cytoplasm . Nucleus . Cytoplasm, myofibril, sarcomere, Z line .
Gene ID (Human)
2274

UniProtKB · Q14192

Four and a half LIM domains protein 2

FHL2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q14192
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
FHL2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
FHL-2
EC number
—
Processing
—
Secondary accessions
Q13229, Q13644, Q2I5I4, Q5TM15, Q9P294
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

CytoplasmNucleus

PTM

Isopeptide bondPhosphoproteinUbl conjugation

Domain

LIM domainRepeatZinc-finger

Ligand

Metal-bindingZinc

Biological process

TranscriptionTranscription regulation

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