SIK2 rabbit pAb

• Background:

  Catalytic activity:ATP + a protein = ADP + a phosphoprotein., cofactor:Magnesium., enzyme regulation:Activated by phosphorylation on Thr-175 by STK11 in complex with STE20-related adapter-alpha (STRAD alpha) pseudo kinase and CAB39., function:Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators., similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. AMPK subfamily., similarity:Contains 1 protein kinase domain., similarity:Contains 1 UBA domain., subunit:Interacts with and phosphorylates TORC2/CRTC2.

• Description:

  Catalytic activity: ATP + a protein = ADP + a phosphoprotein. Cofactor: Magnesium. enzyme regulation: Activated by phosphorylation on Thr-175 by STK11 in complex with STE20-related adapter-alpha (STRAD alpha) pseudo kinase and CAB39. function: Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators. similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. AMPK subfamily. similarity: Contains 1 protein kinase domain. similarity: Contains 1 UBA domain. subunit: Interacts with and phosphorylates TORC2/CRTC2.

• UniProt:

  Q9H0K1

• Swiss Prot:

  Q9H0K1

• Reactivity:

  Human; Mouse

• Immunogen:

  Synthesized peptide derived from part region of human protein

• Clonality:

  Polyclonal

• Source:

  Rabbit

• Applications:

  WB; ELISA

• Concentration:

  1 mg/ml

• Dilution:

  WB 1:500-2000 ELISA 1:5000-20000

• Molecular Weight:

  101kD

• Storage Conditions:

  -20°C/1 year

• Observed Molecular Weight:

  101kD

• Fragment:

  IgG

• Subcellular Location:

  Cytoplasm . Endoplasmic reticulum membrane .

• Gene ID (Human):

  23235