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BAP1 rabbit pAb

CAT: 0855-ES10425-02Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0855-ES10425-02Size:100 µL
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Background
This gene belongs to the ubiquitin C-terminal hydrolase subfamily of deubiquitinating enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition, the enzyme may be involved in regulation of transcription, regulation of cell cycle and growth, response to DNA damage and chromatin dynamics. Germline mutations in this gene may be associated with tumor predisposition syndrome (TPDS), which involves increased risk of cancers including malignant mesothelioma, uveal melanoma and cutaneous melanoma. [provided by RefSeq, May 2013]
Description
This gene belongs to the ubiquitin C-terminal hydrolase subfamily of deubiquitinating enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition, the enzyme may be involved in regulation of transcription, regulation of cell cycle and growth, response to DNA damage and chromatin dynamics. Germline mutations in this gene may be associated with tumor predisposition syndrome (TPDS), which involves increased risk of cancers including malignant mesothelioma, uveal melanoma and cutaneous melanoma. [provided by RefSeq, May 2013],
UniProt
Q92560
Swiss Prot
Q92560
Reactivity
Human; Rat; Mouse
Immunogen
Synthesized peptide derived from human protein . at AA range: 150-230
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Molecular Weight
80kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
80kD
Fragment
IgG
Subcellular Location
Cytoplasm . Nucleus . Mainly nuclear. Binds to chromatin. Localizes to the cytoplasm when monoubiquitinated by the E2/E3 hybrid ubiquitin-protein ligase UBE2O (PubMed:24703950) . .
Gene ID (Human)
8314

UniProtKB · Q92560

Ubiquitin carboxyl-terminal hydrolase BAP1

BAP1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q92560
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
BAP1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.4.19.12
Processing
—
Secondary accessions
A8K993, Q6LEM0, Q7Z5E8
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Molecular function

Chromatin regulatorDevelopmental proteinHydrolaseProteaseThiol protease

Cellular component

ChromosomeCytoplasmNucleus

Domain

Coiled coil

Biological process

DifferentiationUbl conjugation pathway

Disease

Disease variantIntellectual disability

PTM

PhosphoproteinUbl conjugation

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