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SYT14 rabbit pAb

CAT: 0855-ES10332-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES10332-01Size:50 µL
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Background
Synaptotagmin 14 (SYT14) Homo sapiens This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that mediate membrane trafficking in synaptic transmission. The encoded protein is a calcium-independent synaptotagmin. Mutations in this gene are a cause of autosomal recessive spinocerebellar ataxia-11 (SCAR11), and a t (1;3) translocation of this gene has been associated with neurodevelopmental abnormalities. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 4. [provided by RefSeq, Dec 2011]
Description
Synaptotagmin 14 (SYT14) Homo sapiens This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that mediate membrane trafficking in synaptic transmission. The encoded protein is a calcium-independent synaptotagmin. Mutations in this gene are a cause of autosomal recessive spinocerebellar ataxia-11 (SCAR11), and a t (1;3) translocation of this gene has been associated with neurodevelopmental abnormalities. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 4. [provided by RefSeq, Dec 2011],
UniProt
Q8NB59
Swiss Prot
Q8NB59
Reactivity
Human; Mouse
Immunogen
Synthesized peptide derived from part region of human protein
Target
SYT14
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Buffer
-20°C/1 year
Molecular Weight
61kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
61kD
Fragment
IgG
Subcellular Location
Membrane ; Single-pass type III membrane protein . Localized in perinuclear and submembranous regions.
Gene ID (Human)
255928

UniProtKB · Q8NB59

Synaptotagmin-14

SYT14_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q8NB59
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
SYT14
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B1AJU0, B1AJU1, F5H426, Q5THX7, Q707N3, Q707N4, Q707N5, Q707N6, Q707N7
Protein keywords

Coding sequence diversity

Alternative splicing

Disease

Disease variantNeurodegeneration

Cellular component

Membrane

Technical term

Proteomics identificationReference proteome

Domain

RepeatSignal-anchorTransmembraneTransmembrane helix

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