PLK4 rabbit pAb

• Background :

  This gene encodes a member of the polo family of serine/threonine protein kinases. The protein localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centriole duplication during the cell cycle. Three alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

• Description :

  This gene encodes a member of the polo family of serine/threonine protein kinases. The protein localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centriole duplication during the cell cycle. Three alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jun 2010],

• UniProt :

  O00444

• Swiss Prot :

  O00444

• Reactivity :

  Human; Rat; Mouse

• Immunogen :

  Synthesized peptide derived from part region of human protein

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  WB 1:500-2000 ELISA 1:5000-20000

• Molecular Weight :

  106kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  106kD

• Fragment :

  IgG

• Subcellular Location :

  Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Nucleus, nucleolus . Cleavage furrow . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells that can generate more than 100 centrioles. Associates with centrioles throughout the cell cycle. According to PubMed:16244668, it is not present at cleavage furrows.

• Gene ID (Human) :

  10733