ROBO1 rabbit pAb

CAT: 0855-ES10191-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0855-ES10191-01Size:50 µL
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Background
Bilateral symmetric nervous systems have special midline structures that establish a partition between the two mirror image halves. Some axons project toward and across the midline in response to long-range chemoattractants emanating from the midline. The product of this gene is a member of the immunoglobulin gene superfamily and encodes an integral membrane protein that functions in axon guidance and neuronal precursor cell migration. This receptor is activated by SLIT-family proteins, resulting in a repulsive effect on glioma cell guidance in the developing brain. A related gene is located at an adjacent region on chromosome 3. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Description
Bilateral symmetric nervous systems have special midline structures that establish a partition between the two mirror image halves. Some axons project toward and across the midline in response to long-range chemoattractants emanating from the midline. The product of this gene is a member of the immunoglobulin gene superfamily and encodes an integral membrane protein that functions in axon guidance and neuronal precursor cell migration. This receptor is activated by SLIT-family proteins, resulting in a repulsive effect on glioma cell guidance in the developing brain. A related gene is located at an adjacent region on chromosome 3. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009],
UniProt
Q9Y6N7
Swiss Prot
Q9Y6N7
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized peptide derived from human protein . at AA range: 730-810
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Molecular Weight
181kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
181kD
Fragment
IgG
Subcellular Location
Cell membrane ; Single-pass type I membrane protein . Cell projection, axon . Endoplasmic reticulum-Golgi intermediate compartment membrane ; Single-pass membrane protein . Detected at growth cones in thalamus neurons. Detected at growth cones in thalamus neurons (By similarity) . PRRG4 prevents cell surface location and both colocalize in the Endoplasmic reticulum/Golgi adjacent to the cell nucleus (By similarity) . .
Gene ID (Human)
6091

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