GRP3 rabbit pAb

CAT: 0855-ES10101-02Size: 100 µLDry Ice: NoHazardous: No

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CAT#:0855-ES10101-02Size:100 µL

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

RAS guanyl releasing protein 3 (RASGRP3) Homo sapiens Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RASGRP3, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]) .[supplied by OMIM, Mar 2008]

Description

RAS guanyl releasing protein 3 (RASGRP3) Homo sapiens Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RASGRP3, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al. 2000 [PubMed 10934204]). [supplied by OMIM, Mar 2008],

UniProt

Q8IV61

Swiss Prot

Q8IV61

Reactivity

Human; Rat; Mouse

Immunogen

Synthesized peptide derived from human protein . at AA range: 90-170

Clonality

Polyclonal

Source

Rabbit

Applications

WB; ELISA

Concentration

1 mg/ml

Dilution

WB 1:500-2000 ELISA 1:5000-20000

Molecular Weight

75kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

75kD

Fragment

IgG

Subcellular Location

Intracellular, plasma membrane, integral component of plasma membrane, guanyl-nucleotide exchange factor complex, perinuclear region of cytoplasm

Gene ID (Human)

25780

UniProtKB · Q8IV61

Ras guanyl-releasing protein 3

GRP3_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: Q8IV61
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: RASGRP3
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: —
Processing: —
Secondary accessions: D6W583, O94931, Q53SD7

Protein keywords

Coding sequence diversity

Alternative splicing

Ligand

CalciumMetal-bindingZinc

Molecular function

Guanine-nucleotide releasing factor

Technical term

Proteomics identificationReference proteome

Domain

RepeatZinc-finger

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