PLS1 rabbit pAb

• Background:

  Cofactor:Calcium., function:May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system., function:May play a role in the antiviral response of interferon (IFN) by amplifying and enhancing the IFN response through increased expression of select subset of potent antiviral genes. May contribute to cytokine-regulated cell proliferation and differentiation., induction:By phosphorylation by PKC. Induced by INFB1 in response to a viral infection., online information:Scramblase entry, PTM:Known to be palmitoylated at one, yet undefined, site., similarity:Belongs to the phospholipid scramblase family., subunit:Interacts with ABL., tissue specificity:Expressed in platelets, erythrocyte membranes, lymphocytes, spleen, thymus, prostate, testis, uterus, intestine, colon, heart, placenta, lung, liver, kidney and pancreas. Not detected in brain and skeletal muscle.

• Description:

  Cofactor: Calcium. function: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system. function: May play a role in the antiviral response of interferon (IFN) by amplifying and enhancing the IFN response through increased expression of select subset of potent antiviral genes. May contribute to cytokine-regulated cell proliferation and differentiation. induction: By phosphorylation by PKC. Induced by INFB1 in response to a viral infection. online information: Scramblase entry, PTM: Known to be palmitoylated at one, yet undefined, site. similarity: Belongs to the phospholipid scramblase family. subunit: Interacts with ABL. tissue specificity: Expressed in platelets, erythrocyte membranes, lymphocytes, spleen, thymus, prostate, testis, uterus, intestine, colon, heart, placenta, lung, liver, kidney and pancreas. Not detected in brain and skeletal muscle.

• Gene ID:

  5359

• UniProt:

  O15162

• Cellular Locus:

  Cell membrane ; Single-pass type II membrane protein. Cell membrane ; Lipid-anchor ; Cytoplasmic side. Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Localizes to the perinuclear region in the presence of RELT (PubMed:22052202). Palmitoylation regulates its localization to the cell membrane or the nucleus; trafficking to the cell membrane is dependent upon palmitoylation whereas in the absence of palmitoylation, localizes to the nucleus (PubMed:12564925)..

• Host:

  Rabbit

• Species Reactivity:

  Human, Rat, Mouse,

• Reactivity:

  Human; Rat; Mouse

• Immunogen:

  Synthesized peptide derived from human protein . at AA range: 170-250

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Source:

  Rabbit

• Applications:

  WB, ELISA

• Validated Applications:

  WB, ELISA

• Stability:

  -20°C/1 year

• Concentration:

  1 mg/mL

• Dilution:

  WB 1:500-2000 ELISA 1:5000-20000

• Molecular Weight:

  34kD

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

• Observed Molecular Weight:

  34 kD

• Subcellular Location:

  Cell membrane ; Single-pass type II membrane protein . Cell membrane ; Lipid-anchor ; Cytoplasmic side. Nucleus . Cytoplasm . Cytoplasm, perinuclear region . Localizes to the perinuclear region in the presence of RELT (PubMed:22052202) . Palmitoylation regulates its localization to the cell membrane or the nucleus; trafficking to the cell membrane is dependent upon palmitoylation whereas in the absence of palmitoylation, localizes to the nucleus (PubMed:12564925) . .

• Gene ID (Human):

  5359

• SwissProt (Human):

  O15162