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FANCM rabbit pAb

CAT: 0855-ES9658-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES9658-01Size:50 µL
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Background
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2) . The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group M. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Description
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group M. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015],
UniProt
Q8IYD8
Swiss Prot
Q8IYD8
Reactivity
Human; Rat; Mouse
Immunogen
Synthesized peptide derived from part region of human protein
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Molecular Weight
225kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
225kD
Fragment
IgG
Subcellular Location
Nucleus .
Gene ID (Human)
57697

UniProtKB · Q8IYD8

Fanconi anemia group M protein

FANCM_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q8IYD8
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
FANCM
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
Protein FACM
EC number
3.6.4.13
Processing
—
Secondary accessions
B2RTQ9, Q3YFH9, Q8N9X6, Q9HCH6
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingNucleotide-binding

Disease

Disease variantPremature ovarian failure

Biological process

DNA damageDNA repair

Molecular function

DNA-bindingHelicaseHydrolase

Cellular component

Nucleus

PTM

Phosphoprotein

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