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HECW1 rabbit pAb

CAT: 0855-ES9625-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES9625-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Function:E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS) . Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS., pathway:Protein modification; protein ubiquitination., similarity:Contains 1 C2 domain., similarity:Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain., similarity:Contains 2 WW domains., subunit:Interacts with DVL1 and SSR3. Also interacts with mutant SOD1., tissue specificity:Predominantly expressed in neurons of adult and fetal brain. Weakly expressed in the kidney.
Description
Function: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS. pathway: Protein modification; protein ubiquitination. similarity: Contains 1 C2 domain. similarity: Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain. similarity: Contains 2 WW domains. subunit: Interacts with DVL1 and SSR3. Also interacts with mutant SOD1. tissue specificity: Predominantly expressed in neurons of adult and fetal brain. Weakly expressed in the kidney.
UniProt
Q76N89
Swiss Prot
Q76N89
Reactivity
Human; Rat; Mouse
Immunogen
Synthesized peptide derived from part region of human protein. AA range: 1-67
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Molecular Weight
176kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
176kD
Fragment
IgG
Subcellular Location
Cytoplasm .
Gene ID (Human)
23072

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