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DNA2 rabbit pAb

CAT: 0855-ES9598-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES9598-01Size:50 µL
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Background
This gene encodes a member of the DNA2/NAM7 helicase family. The encoded protein is a conserved helicase/nuclease involved in the maintenance of mitochondrial and nuclear DNA stability. Mutations in this gene are associated with autosomal dominant progressive external ophthalmoplegia-6 (PEOA6) and Seckel syndrome 8. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014]
Description
This gene encodes a member of the DNA2/NAM7 helicase family. The encoded protein is a conserved helicase/nuclease involved in the maintenance of mitochondrial and nuclear DNA stability. Mutations in this gene are associated with autosomal dominant progressive external ophthalmoplegia-6 (PEOA6) and Seckel syndrome 8. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014],
UniProt
P51530
Swiss Prot
P51530
Reactivity
Human; Mouse
Immunogen
Synthesized peptide derived from part region of human protein
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Molecular Weight
116kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
116kD
Fragment
IgG
Subcellular Location
Nucleus. Mitochondrion. Was initially reported to be exclusively mitochondrial (PubMed:18995831) . However, it was later shown to localize both in mitochondrion and nucleus (PubMed:19487465) . .
Gene ID (Human)
1763

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