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CIDEA rabbit pAb

CAT: 0855-ES9248-02Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0855-ES9248-02Size:100 µL
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Background
Cell death-inducing DFFA-like effector a (CIDEA) Homo sapiens This gene encodes the homolog of the mouse protein Cidea that has been shown to activate apoptosis. This activation of apoptosis is inhibited by the DNA fragmentation factor DFF45 but not by caspase inhibitors. Mice that lack functional Cidea have higher metabolic rates, higher lipolysis in brown adipose tissue and higher core body temperatures when subjected to cold. These mice are also resistant to diet-induced obesity and diabetes. This suggests that in mice this gene product plays a role in thermogenesis and lipolysis. Alternatively spliced transcripts have been identified. [provided by RefSeq, Aug 2010]
Description
Cell death-inducing DFFA-like effector a (CIDEA) Homo sapiens This gene encodes the homolog of the mouse protein Cidea that has been shown to activate apoptosis. This activation of apoptosis is inhibited by the DNA fragmentation factor DFF45 but not by caspase inhibitors. Mice that lack functional Cidea have higher metabolic rates, higher lipolysis in brown adipose tissue and higher core body temperatures when subjected to cold. These mice are also resistant to diet-induced obesity and diabetes. This suggests that in mice this gene product plays a role in thermogenesis and lipolysis. Alternatively spliced transcripts have been identified. [provided by RefSeq, Aug 2010],
UniProt
O60543
Swiss Prot
O60543
Reactivity
Human; Rat; Mouse
Immunogen
Synthesized peptide derived from human protein . at AA range: 140-220
Target
CIDEA
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Buffer
-20°C/1 year
Molecular Weight
24kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
24kD
Fragment
IgG
Subcellular Location
Lipid droplet . Nucleus . Enriched at lipid droplet contact sites. Has been shown to localize to mitochondria, where it could interact with UCP1 and hence inhibit UCP1 uncoupling activity (By similarity) . These data could not be confirmed (PubMed:18509062) . .
Gene ID (Human)
1149

UniProtKB · O60543

Lipid transferase CIDEA

CIDEA_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O60543
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CIDEA
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B0YIY7, Q6UPR7
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Molecular function

Activator

Biological process

ApoptosisTranscriptionTranscription regulation

Cellular component

Lipid dropletNucleus

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