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PLCD1 rabbit pAb

CAT: 0855-ES9222-02Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0855-ES9222-02Size:100 µL
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Background
This gene encodes a member of the phospholipase C family. Phospholipase C isozymes play critical roles in intracellular signal transduction by catalyzing the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) into the second messengers diacylglycerol (DAG) and inositol triphosphate (IP3) . The encoded protein functions as a tumor suppressor in several types of cancer, and mutations in this gene are a cause of hereditary leukonychia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Description
This gene encodes a member of the phospholipase C family. Phospholipase C isozymes play critical roles in intracellular signal transduction by catalyzing the hydrolysis of phosphatidylinositol 4, 5-bisphosphate (PIP2) into the second messengers diacylglycerol (DAG) and inositol triphosphate (IP3). The encoded protein functions as a tumor suppressor in several types of cancer, and mutations in this gene are a cause of hereditary leukonychia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011],
UniProt
P51178
Swiss Prot
P51178
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized peptide derived from human protein . at AA range: 90-170
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Molecular Weight
83kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
83kD
Fragment
IgG
Subcellular Location
Intracellular, cytoplasm, cytosol, plasma membrane, extracellular exosome
Gene ID (Human)
5333

UniProtKB · P51178

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1

PLCD1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P51178
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PLCD1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.1.4.11
Processing
—
Secondary accessions
B3KR14, Q86VN8
Protein keywords

Coding sequence diversity

Alternative splicing

Ligand

CalciumMetal-binding

Cellular component

Cell membraneCytoplasmMembrane

Disease

Disease variant

PTM

GlycoproteinPhosphoprotein

Molecular function

HydrolaseTransducer

Biological process

Lipid degradationLipid metabolism

Technical term

Proteomics identificationReference proteome

Domain

Repeat

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