NACA rabbit pAb

• Background:

  This gene encodes a protein that associates with basic transcription factor 3 (BTF3) to form the nascent polypeptide-associated complex (NAC) . This complex binds to nascent proteins that lack a signal peptide motif as they emerge from the ribosome, blocking interaction with the signal recognition particle (SRP) and preventing mistranslocation to the endoplasmic reticulum. This protein is an IgE autoantigen in atopic dermatitis patients. Alternative splicing results in multiple transcript variants, but the full length nature of some of these variants, including those encoding very large proteins, has not been determined. There are multiple pseudogenes of this gene on different chromosomes. [provided by RefSeq, Feb 2016]

• Description:

  This gene encodes a protein that associates with basic transcription factor 3 (BTF3) to form the nascent polypeptide-associated complex (NAC). This complex binds to nascent proteins that lack a signal peptide motif as they emerge from the ribosome, blocking interaction with the signal recognition particle (SRP) and preventing mistranslocation to the endoplasmic reticulum. This protein is an IgE autoantigen in atopic dermatitis patients. Alternative splicing results in multiple transcript variants, but the full length nature of some of these variants, including those encoding very large proteins, has not been determined. There are multiple pseudogenes of this gene on different chromosomes. [provided by RefSeq, Feb 2016],

• UniProt:

  Q13765

• Swiss Prot:

  Q13765

• Reactivity:

  Human; Mouse; Rat

• Immunogen:

  Synthesized peptide derived from human protein . at AA range: 100-180

• Clonality:

  Polyclonal

• Source:

  Rabbit

• Applications:

  WB; ELISA

• Concentration:

  1 mg/ml

• Dilution:

  WB 1:500-2000 ELISA 1:5000-20000

• Molecular Weight:

  23kD

• Storage Conditions:

  -20°C/1 year

• Observed Molecular Weight:

  23kD

• Fragment:

  IgG

• Subcellular Location:

  Cytoplasm . Nucleus . The heterodimer is located mainly in the cytosol, and the homodimer in the nucleus. .

• Gene ID (Human):

  4666