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PCNA rabbit pAb

CAT: 0855-ES8839-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES8839-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome. [provided by RefSeq, Jul 2008]
Description
The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome. [provided by RefSeq, Jul 2008],
Product Name Alternative
Proliferating cell nuclear antigen (PCNA) (Cyclin)
UniProt
P12004
Swiss Prot
P12004
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized peptide derived from human PCNA. at AA range: Internal
Target
PCNA
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA; IHC
Concentration
1 mg/ml
Dilution
WB 1:500-2000; IHC-p 1:50-300; ELISA 2000-20000
Buffer
-20°C/1 year
Molecular Weight
30-33kd
Storage Conditions
-20°C/1 year
Observed Molecular Weight
30-33kd
Fragment
IgG
Subcellular Location
Nucleus . Colocalizes with CREBBP, EP300 and POLD1 to sites of DNA damage (PubMed:24939902) . Forms nuclear foci representing sites of ongoing DNA replication and vary in morphology and number during S phase (PubMed:15543136) . Co-localizes with SMARCA5/SNF2H and BAZ1B/WSTF at replication foci during S phase (PubMed:15543136) . Together with APEX2, is redistributed in discrete nuclear foci in presence of oxidative DNA damaging agents. .
Other Product Names
Proliferating cell nuclear antigen (PCNA) (Cyclin)
Gene ID (Human)
5111

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