CD1A/B rabbit pAb

CD1A/B rabbit pAb

• Description: This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to the plasma membrane and to recycling vesicles of the early endocytic system. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016],
• Gene ID: 909/910
• UniProt: P06126/P29016
• Cellular Locus: Cell membrane ; Single-pass type I membrane protein. Membrane raft ; Single-pass type I membrane protein. Endosome membrane ; Single-pass type I membrane protein. Subject to intracellular trafficking between the cell membrane and endosomes (PubMed:11231314). Localizes to cell surface lipid rafts (PubMed:18178838)..
• Host: Rabbit
• Species Reactivity: Human, Rat, Mouse,
• Immunogen: Synthetic peptide from human protein at AA range: 220-270
• Clonality: Polyclonal
• Validated Applications: IHC, IF, ELISA
• Stability: 1 year
• Concentration: 1 mg/mL
• Dilution: IHC-p 1:50-200, ELISA 1:10000-20000
• Storage Conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.