Bob 1 rabbit pAb

Bob 1 rabbit pAb

• Description: Disease: A chromosomal aberration involving POU2AF1/OBF1 may be a cause of a form of B-cell leukemia. Translocation t (3;11) (q27;q23) with BCL6. function: Transcriptional coactivator that specifically associates with either OCT1 or OCT2. It boosts the OCT1 mediated promoter activity and to a lesser extent, that of OCT2. It has no intrinsic DNA-binding activity. It recognizes the POU domains of OCT1 and OCT2. It is essential for the response of B-cells to antigens and required for the formation of germinal centers. PTM: Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation. similarity: Belongs to the POU2AF1 family. tissue specificity: B-cell specific.
• Synonyms: POU domain class 2-associating factor 1 (B-cell-specific coactivator OBF-1;BOB-1;OCA-B;OCT-binding factor 1)
• Gene ID: 5450
• UniProt: Q16633
• Cellular Locus: Nucleus.
• Host: Rabbit
• Species Reactivity: Human, Rat, Mouse,
• Immunogen: Synthetic peptide from human protein at AA range: 201-250
• Clonality: Polyclonal
• Validated Applications: IHC, IF, ELISA
• Stability: 1 year
• Concentration: 1 mg/mL
• Dilution: IHC-p 1:50-200, ELISA 1:10000-20000
• Storage Conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.