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Bob 1 rabbit pAb

CAT: 0855-ES8740-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES8740-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Disease:A chromosomal aberration involving POU2AF1/OBF1 may be a cause of a form of B-cell leukemia. Translocation t (3;11) (q27; q23) with BCL6., function:Transcriptional coactivator that specifically associates with either OCT1 or OCT2. It boosts the OCT1 mediated promoter activity and to a lesser extent, that of OCT2. It has no intrinsic DNA-binding activity. It recognizes the POU domains of OCT1 and OCT2. It is essential for the response of B-cells to antigens and required for the formation of germinal centers., PTM:Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation., similarity:Belongs to the POU2AF1 family., tissue specificity:B-cell specific.
Description
Disease: A chromosomal aberration involving POU2AF1/OBF1 may be a cause of a form of B-cell leukemia. Translocation t (3;11) (q27;q23) with BCL6. function: Transcriptional coactivator that specifically associates with either OCT1 or OCT2. It boosts the OCT1 mediated promoter activity and to a lesser extent, that of OCT2. It has no intrinsic DNA-binding activity. It recognizes the POU domains of OCT1 and OCT2. It is essential for the response of B-cells to antigens and required for the formation of germinal centers. PTM: Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation. similarity: Belongs to the POU2AF1 family. tissue specificity: B-cell specific.
UniProt
Q16633
Swiss Prot
Q16633
Reactivity
Human; Rat; Mouse
Immunogen
Synthetic peptide from human protein at AA range: 201-250
Clonality
Polyclonal
Source
Rabbit
Applications
IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
IHC-p 1:50-200, ELISA 1:10000-20000
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Nucleus .
Other Product Names
POU domain class 2-associating factor 1 (B-cell-specific coactivator OBF-1; BOB-1; OCA-B; OCT-binding factor 1)
Gene ID (Human)
5450

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