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HDGF rabbit pAb

CAT: 0855-ES8731-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES8731-01Size:50 µL
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Background
This gene encodes a member of the hepatoma-derived growth factor family. The encoded protein has mitogenic and DNA-binding activity and may play a role in cellular proliferation and differentiation. High levels of expression of this gene enhance the growth of many tumors. This gene was thought initially to be located on chromosome X; however, that location has been determined to correspond to a related pseudogene. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jan 2016]
Description
This gene encodes a member of the hepatoma-derived growth factor family. The encoded protein has mitogenic and DNA-binding activity and may play a role in cellular proliferation and differentiation. High levels of expression of this gene enhance the growth of many tumors. This gene was thought initially to be located on chromosome X; however, that location has been determined to correspond to a related pseudogene. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jan 2016],
UniProt
P51858
Swiss Prot
P51858
Reactivity
Human; Rat; Mouse
Immunogen
Synthetic peptide from human protein at AA range: 141-190
Clonality
Polyclonal
Source
Rabbit
Applications
IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
IHC-p 1:50-200, ELISA 1:10000-20000
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
[Isoform 1]: Nucleus . Cytoplasm . Secreted, extracellular exosome . Secreted by exosomes and is located inside the exosome (PubMed:27926477) . May also be secreted as free protein via an as yet unknown pathway (PubMed:27926477) . .; [Isoform 2]: Nucleus . Cytoplasm . Secreted, extracellular exosome . Secreted by exosomes and is located on the outer exosome surface. .; [Isoform 3]: Nucleus . Cytoplasm . Secreted, extracellular exosome . Secreted by exosomes and is located on the outer exosome surface. .
Other Product Names
Hepatoma-derived growth factor (HDGF; High mobility group protein 1-like 2; HMG-1L2)
Gene ID (Human)
3068

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