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CD299 rabbit pAb

CAT: 0855-ES8703-02Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0855-ES8703-02Size:100 µL
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Background
This gene encodes a transmembrane receptor and is often referred to as L-SIGN because of its expression in the endothelial cells of the lymph nodes and liver. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses, with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations
Description
This gene encodes a transmembrane receptor and is often referred to as L-SIGN because of its expression in the endothelial cells of the lymph nodes and liver. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses, with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations
UniProt
Q9H2X3
Swiss Prot
Q9H2X3
Reactivity
Human; Mouse; Rat
Immunogen
Synthetic peptide from human protein at AA range: 271-320
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000, IHC-p 1:500-200, ELISA 1:10000-20000
Molecular Weight
60kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
60kD
Fragment
IgG
Subcellular Location
[Isoform 1]: Cell membrane ; Single-pass type II membrane protein .; [Isoform 2]: Cell membrane ; Single-pass type II membrane protein .; [Isoform 3]: Cell membrane ; Single-pass type II membrane protein .; [Isoform 5]: Secreted .; [Isoform 6]: Secreted .; [Isoform 7]: Secreted .; [Isoform 10]: Secreted .
Other Product Names
C-type lectin domain family 4 member M (CD209 antigen-like protein 1; DC-SIGN-related protein; DC-SIGNR; Dendritic cell-specific ICAM-3-grabbing non-integrin 2; DC-SIGN2; Liver/lymph node-specific ICAM-3-grabbing non-integrin; L-SIGN; CD antigen CD299)
Gene ID (Human)
10332

UniProtKB · Q9H2X3

C-type lectin domain family 4 member M

CLC4M_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9H2X3
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CLEC4M
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
A6NKI4, A8K8B3, Q69F40, Q969M4, Q96QP3, Q96QP4, Q96QP5, Q96QP6, Q9BXS3, Q9H2Q9, Q9H8F0, Q9Y2A8
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Biological process

Adaptive immunityEndocytosisHost-virus interactionImmunityInnate immunity

Coding sequence diversity

Alternative splicing

Ligand

CalciumLectinMannose-bindingMetal-binding

Cellular component

Cell membraneMembraneSecreted

PTM

Disulfide bondGlycoprotein

Molecular function

Host cell receptor for virus entryReceptor

Domain

RepeatSignal-anchorTransmembraneTransmembrane helix

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