CIS rabbit pAb

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Background

Cytokine inducible SH2 containing protein (CISH) Homo sapiens The protein encoded by this gene contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

Description

Cytokine inducible SH2 containing protein (CISH) Homo sapiens The protein encoded by this gene contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of Cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of Cytokine signaling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008],

UniProt

Q9NSE2

Swiss Prot

Q9NSE2

Reactivity

Human; Mouse; Rat

Immunogen

Synthetic peptide from human protein at AA range: 30-90

Clonality

Polyclonal

Source

Rabbit

Applications

IHC; IF; ELISA

Concentration

1 mg/ml

Dilution

IHC-p 1:50-200, ELISA 1:10000-20000

Storage Conditions

-20°C/1 year

Fragment

IgG

Subcellular Location

Cytoplasm, cytosol, plasma membrane

Other Product Names

Cytokine-inducible SH2-containing protein (CIS; CIS-1; Protein G18; Suppressor of cytokine signaling; SOCS)

Gene ID (Human)

1154

UniProtKB · Q9NSE2

Cytokine-inducible SH2-containing protein

CISH_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: Q9NSE2
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: CISH
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: CIS
EC number: —
Processing: —
Secondary accessions: B2R9N1, G5E9R1, Q9NS38, Q9Y5R1

Protein keywords

Coding sequence diversity

Alternative splicing

Biological process

Growth regulationUbl conjugation pathway

Technical term

Proteomics identificationReference proteome

Domain

SH2 domain

Molecular function

Signal transduction inhibitor

PTM

Ubl conjugation

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