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MLL rabbit pAb

CAT: 0855-ES8669-02Size: 100 µLDry Ice: NoHazardous: No
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Background
This gene encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. The encoded protein contains multiple conserved functional domains. One of these domains, the SET domain, is responsible for its histone H3 lysine 4 (H3K4) methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. This protein is processed by the enzyme Taspase 1 into two fragments, MLL-C and MLL-N. These fragments reassociate and further assemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes. Multiple chromosomal translocations involving this gene are the cause of certain acute lymphoid leukemias and acute myeloid leukemias. Alternate splicing results in multiple transcript variants.[provided by RefS
Description
This gene encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. The encoded protein contains multiple conserved functional domains. One of these domains, the SET domain, is responsible for its histone H3 lysine 4 (H3K4) methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. This protein is processed by the enzyme Taspase 1 into two fragments, MLL-C and MLL-N. These fragments reassociate and further assemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes. Multiple chromosomal translocations involving this gene are the cause of certain acute lymphoid leukemias and acute myeloid leukemias. Alternate splicing results in multiple transcript variants. [provided by RefS
UniProt
Q03164
Swiss Prot
Q03164
Reactivity
Human; Mouse; Rat
Immunogen
Synthetic peptide from human protein at AA range: 3850-3900
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Nucleus .; [MLL cleavage product N320]: Nucleus.; [MLL cleavage product C180]: Nucleus. Localizes to a diffuse nuclear pattern when not associated with MLL cleavage product N320.
Other Product Names
Histone-lysine N-methyltransferase MLL (EC 2.1.1.43; ALL-1; CXXC-type zinc finger protein 7; Lysine N-methyltransferase 2A; KMT2A; Trithorax-like protein; Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa; p320) ; MLL cleavage product C180 (C-terminal cleavage product of 180 kDa; p180) ]
Gene ID (Human)
4297

UniProtKB · Q03164

Histone-lysine N-methyltransferase 2A

KMT2A_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q03164
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
KMT2A
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
Lysine N-methyltransferase 2A
EC number
2.1.1.364
Processing
—
Secondary accessions
E9PQG7, Q13743, Q13744, Q14845, Q16364, Q59FF2, Q6UBD1, Q9HBJ3, Q9UD94, Q9UMA3
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationIsopeptide bondMethylationPhosphoproteinUbl conjugation

Coding sequence diversity

Alternative splicingChromosomal rearrangement

Biological process

ApoptosisBiological rhythmsHost-virus interactionTranscriptionTranscription regulation

Domain

BromodomainRepeatZinc-finger

Molecular function

Chromatin regulatorDNA-bindingMethyltransferaseTransferase

Ligand

Metal-bindingS-adenosyl-L-methionineZinc

Cellular component

Nucleus

Disease

Proto-oncogene

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