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SOCS-3 rabbit pAb

CAT: 0855-ES8666-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES8666-01Size:50 µL
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Background
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN) -gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development. [provided by RefSeq, Jul 2008]
Description
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of Cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of Cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development. [provided by RefSeq, Jul 2008],
UniProt
O14543
Swiss Prot
O14543
Reactivity
Human; Mouse; Rat
Immunogen
Synthetic peptide from human protein at AA range: 20-70
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000.IHC-p:1:50-300. Not yet tested in other applications.
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Intracellular, cytoplasm, cytosol
Other Product Names
Suppressor of cytokine signaling 3 (SOCS-3; Cytokine-inducible SH2 protein 3; CIS-3; STAT-induced STAT inhibitor 3; SSI-3)
Gene ID (Human)
9021

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