14-3-3 σ rabbit pAb

CAT: 0855-ES5572-01Size: 50 µLDry Ice: NoHazardous: No

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CAT#:0855-ES5572-01Size:50 µL

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Background

Function:Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway., function:p53-regulated inhibitor of G2/M progression., similarity:Belongs to the 14-3-3 family., subcellular location:May be secreted by a non-classical secretory pathway., subunit:Homodimer. Interacts with KRT17 (By similarity) . Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN., tissue specificity:Present mainly in tissues enriched in stratified squamous keratinising epithelium.

Description

Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. function: p53-regulated inhibitor of G2/M progression. similarity: Belongs to the 14-3-3 family. subcellular location: May be secreted by a non-classical secretory pathway. subunit: Homodimer. Interacts with KRT17 (By similarity). Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN. tissue specificity: Present mainly in tissues enriched in stratified squamous keratinising epithelium.

UniProt

P31947

Swiss Prot

P31947

Reactivity

Human; Mouse

Immunogen

The antiserum was produced against synthesized peptide derived from human SFN. AA range:41-90

Clonality

Polyclonal

Source

Rabbit

Applications

WB; IHC; IF; ELISA

Concentration

1 mg/ml

Dilution

IHC-p: 100-300.Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.

Molecular Weight

30kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

30kD

Fragment

IgG

Subcellular Location

Cytoplasm. Nucleus . Secreted. May be secreted by a non-classical secretory pathway.

Other Product Names

SFN; HME1; 14-3-3 protein sigma; Epithelial cell marker protein 1; Stratifin

Gene ID (Human)

2810

UniProtKB · P31947

14-3-3 protein sigma

1433S_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P31947
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: SFN
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: —
Processing: —
Secondary accessions: Q6FH30, Q6FH51, Q96DH0

Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

CytoplasmNucleusSecreted

PTM

PhosphoproteinUbl conjugation

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