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Dsg1 rabbit pAb

CAT: 0855-ES8660-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES8660-01Size:50 µL
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Background
This gene encodes a member of the desmoglein protein subfamily. Desmogleins, along with desmocollins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmoglein family members on chromosome 18. The encoded protein has been identified as a target of auto-antibodies in the autoimmune skin blistering disease pemphigus foliaceus. Disruption of this gene has also been associated with the skin diseases palmoplantar keratoderma and erythroderma. [provided by RefSeq, Feb 2015]
Description
This gene encodes a member of the desmoglein protein subfamily. Desmogleins, along with desmocollins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmoglein family members on chromosome 18. The encoded protein has been identified as a target of auto-antibodies in the autoimmune skin blistering disease pemphigus foliaceus. Disruption of this gene has also been associated with the skin diseases palmoplantar keratoderma and erythroderma. [provided by RefSeq, Feb 2015],
UniProt
Q02413
Swiss Prot
Q02413
Reactivity
Human; Mouse; Rat
Immunogen
Synthetic peptide from human protein at AA range: 30-90
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000, IHC-p 1:500-200, ELISA 1:10000-20000
Molecular Weight
160kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
160kD
Fragment
IgG
Subcellular Location
Cell membrane ; Single-pass type I membrane protein . Cell junction, desmosome.
Other Product Names
Desmoglein-1 (Cadherin family member 4; Desmosomal glycoprotein 1; DG1; DGI; Pemphigus foliaceus antigen)
Gene ID (Human)
1828

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