PI 3 Kinase Class 3 rabbit pAb

PI 3 Kinase Class 3 rabbit pAb

• Description: Catalytic activity: ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate. Cofactor: Manganese. function: Catalytic subunit of the PI3K complex. Involved in the transport of lysosomal enzyme precursors to lysosomes. similarity: Belongs to the PI3/PI4-kinase family. similarity: Contains 1 PI3K/PI4K domain. subunit: Probably forms a complex with AMBRA1 and BECN1 (By similarity). Heterodimer. This subunit, part of a complex composed of regulatory and catalytic subunits, associates with regulatory subunit PIK3R4. tissue specificity: Ubiquitously expressed, with a highest expression in skeletal muscle.
• Synonyms: phosphoinositide-3-kinase, class 3
• Gene ID: 5289
• UniProt: Q8NEB9
• Cellular Locus: Midbody. Late endosome. Cytoplasmic vesicle, autophagosome. As component of the PI3K complex I localized to pre-autophagosome structures. As component of the PI3K complex II localized predominantly to endosomes (PubMed:14617358). Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme (By similarity)..
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat, Predicted:Cow:PIG
• Immunogen: Synthetic Peptide of PI 3 Kinase Class 3
• Clonality: Polyclonal
• Validated Applications: WB, IHC
• Stability: 1 year
• Concentration: 1 mg/mL
• Dilution: WB 1:500-2000;IHC-p 1:50-300
• Molecular Weight: 100kD
• Storage Conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.