PI 3 Kinase Class 3 rabbit pAb

• Background:

  Catalytic activity:ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate., cofactor:Manganese., function:Catalytic subunit of the PI3K complex. Involved in the transport of lysosomal enzyme precursors to lysosomes., similarity:Belongs to the PI3/PI4-kinase family., similarity:Contains 1 PI3K/PI4K domain., subunit:Probably forms a complex with AMBRA1 and BECN1 (By similarity) . Heterodimer. This subunit, part of a complex composed of regulatory and catalytic subunits, associates with regulatory subunit PIK3R4., tissue specificity:Ubiquitously expressed, with a highest expression in skeletal muscle.

• Description:

  Catalytic activity: ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate. Cofactor: Manganese. function: Catalytic subunit of the PI3K complex. Involved in the transport of lysosomal enzyme precursors to lysosomes. similarity: Belongs to the PI3/PI4-kinase family. similarity: Contains 1 PI3K/PI4K domain. subunit: Probably forms a complex with AMBRA1 and BECN1 (By similarity). Heterodimer. This subunit, part of a complex composed of regulatory and catalytic subunits, associates with regulatory subunit PIK3R4. tissue specificity: Ubiquitously expressed, with a highest expression in skeletal muscle.

• Synonyms:

  phosphoinositide-3-kinase, class 3

• Gene ID:

  5289

• UniProt:

  Q8NEB9

• Cellular Locus:

  Midbody. Late endosome. Cytoplasmic vesicle, autophagosome. As component of the PI3K complex I localized to pre-autophagosome structures. As component of the PI3K complex II localized predominantly to endosomes (PubMed:14617358). Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme (By similarity)..

• Host:

  Rabbit

• Species Reactivity:

  Human, Mouse, Rat, Predicted:Cow:PIG

• Reactivity:

  Human; Mouse; Rat; Predicted:Cow:PIG

• Immunogen:

  Synthetic Peptide of PI 3 Kinase Class 3

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Source:

  Rabbit

• Applications:

  WB, IHC

• Validated Applications:

  WB, IHC

• Stability:

  -20°C/1 year

• Concentration:

  1 mg/mL

• Dilution:

  WB 1:500-2000; IHC-p 1:50-300

• Molecular Weight:

  100kD

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

• Observed Molecular Weight:

  100 kD

• Subcellular Location:

  Midbody . Late endosome . Cytoplasmic vesicle, autophagosome . As component of the PI3K complex I localized to pre-autophagosome structures. As component of the PI3K complex II localized predominantly to endosomes (PubMed:14617358) . Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme (By similarity) . .

• Other Product Names:

  Phosphoinositide-3-kinase, class 3

• Gene ID (Human):

  5289

• SwissProt (Human):

  Q8NEB9