Products for Research Use Only
RegisterLogin

Atm (phospho Ser1981) rabbit pAb

CAT: 0855-ES8438-01Size: 50 µLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0855-ES8438-01Size:50 µL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010]
Description
The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010],
UniProt
Q13315
Swiss Prot
Q13315
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized phospho-peptide around the phosphorylation site of human Atm (phospho Ser1981)
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Molecular Weight
350kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
350kD
Fragment
IgG
Subcellular Location
Nucleus . Cytoplasmic vesicle . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Primarily nuclear. Found also in endocytic vesicles in association with beta-adaptin. .
Other Product Names
ATM; Serine-protein kinase ATM; Ataxia telangiectasia mutated; A-T mutated
Gene ID (Human)
472

UniProtKB · Q13315

Serine-protein kinase ATM

ATM_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q13315
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ATM
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.7.11.1
Processing
—
Secondary accessions
B2RNX5, O15429, Q12758, Q16551, Q93007, Q9NP02, Q9UCX7
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationPhosphoprotein

Ligand

ATP-bindingNucleotide-binding

Biological process

Cell cycleDNA damage

Cellular component

CytoplasmCytoplasmic vesicleCytoskeletonNucleusPeroxisome

Disease

Disease variantNeurodegenerationTumor suppressor

Molecular function

DNA-bindingKinaseSerine/threonine-protein kinaseTransferase

Related Products

CatalogName
ES20186-01ATM (Phospho Ser1987) rabbit pAb
ES6349-01Atm rabbit pAb
ES6348-01Atm rabbit pAb
EA323-01ATM Rabbit pAb
ES20823-01ATM Rabbit rabbit pAb
ES20056-01Atm (Acetyl Lys316) rabbit pAb
ES4391-01FADD (phospho Ser191) rabbit pAb
ES8144-01Cdc25C (phospho Ser198) rabbit pAb
ES15309-01KIF1B (phospho-Ser1487) rabbit pAb
ES5396-01MTOR (phospho Ser2481) rabbit pAb

Alternative Products

CatalogName
AB100312ATM (Phospho-Ser1981) Rabbit mAb
E2R380751Phospho-ATM (Ser1981) Rabbit mAb
MBS8576020-01Phospho-ATM (Ser1981) Rabbit pAb
MBS8541496-01ATM (Phospho-Ser1981) Rabbit pAb
UB-GEN-10315CACNA1C (Phospho-Ser1981) rabbit pAb
E60M0785ATM (Phospho Ser1981) Rabbit mAb
HY-P83436-01Phospho-ATM (Ser1981) Antibody (YA3181, Rabbit)
E53P04006Atm phospho-Ser1981 Rabbit Polyclonal Antibody
E47M54103Phospho-ATM (Ser1981) Recombinant Rabbit mAb
SL2272R-01Rabbit Anti-phospho-ATM (Ser1981) antibody

Popular Products