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AKAP 250 rabbit pAb

CAT: 0855-ES8070-01Size: 50 µLDry Ice: NoHazardous: No
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Background
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed in endothelial cells, cultured fibroblasts, and osteosarcoma cells. It associates with protein kinases A and C and phosphatase, and serves as a scaffold protein in signal transduction. This protein and RII PKA colocalize at the cell periphery. This protein is a cell growth-related protein. Antibodies to this protein can be produced by patients with myasthenia gravis. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Description
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed in endothelial cells, cultured fibroblasts, and osteosarcoma cells. It associates with protein kinases A and C and phosphatase, and serves as a scaffold protein in signal transduction. This protein and RII PKA colocalize at the cell periphery. This protein is a cell growth-related protein. Antibodies to this protein can be produced by patients with myasthenia gravis. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],
Product Name Alternative
AKAP12; AKAP250; A-kinase anchor protein 12; AKAP-12; A-kinase anchor protein 250 kDa; AKAP 250; Gravin; Myasthenia gravis autoantigen
UniProt
Q02952
Swiss Prot
Q02952
Reactivity
Human; Rat; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human AKAP12. AA range:301-350
Target
AKAP 250
Clonality
Polyclonal
Source
Rabbit
Applications
IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Buffer
-20°C/1 year
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Cytoplasm, cell cortex . Cytoplasm, cytoskeleton . Membrane ; Lipid-anchor . May be part of the cortical cytoskeleton.
Other Product Names
AKAP12; AKAP250; A-kinase anchor protein 12; AKAP-12; A-kinase anchor protein 250 kDa; AKAP 250; Gravin; Myasthenia gravis autoantigen
Gene ID (Human)
9590

UniProtKB · Q02952

A-kinase anchor protein 12

AKA12_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q02952
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
AKAP12
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
AKAP-12
EC number
—
Processing
—
Secondary accessions
O00310, O00498, Q4LE68, Q5SZ80, Q5TGN1, Q68D82, Q99970
Protein keywords

Coding sequence diversity

Alternative splicing

Molecular function

Calmodulin-binding

Cellular component

CytoplasmCytoskeletonMembrane

PTM

Isopeptide bondLipoproteinMyristatePhosphoproteinUbl conjugation

Technical term

Proteomics identificationReference proteome

Domain

Repeat

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