PERK rabbit pAb
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PERK rabbit pAb
Background :
The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Sep 2015]Description :
The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Sep 2015],UniProt :
Q9NZJ5Swiss Prot :
Q9NZJ5Reactivity :
Human; Mouse; RatImmunogen :
The antiserum was produced against synthesized peptide derived from human EIF2AK3. AA range:947-996Clonality :
PolyclonalSource :
RabbitApplications :
IF; WB; IHC; ELISAConcentration :
1 mg/mlDilution :
IF: 1:50-200 Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.Molecular Weight :
125kDStorage Conditions :
-20°C/1 yearObserved Molecular Weight :
125kDFragment :
IgGSubcellular Location :
Endoplasmic reticulum membrane; Single-pass type I membrane protein.Other Product Names :
EIF2AK3; PEK; PERK; Eukaryotic translation initiation factor 2-alpha kinase 3; PRKR-like endoplasmic reticulum kinase; Pancreatic eIF2-alpha kinase; HsPEKGene ID (Human) :
9451
