Products for Research Use Only
RegisterLogin

Per2 (phospho Ser662) rabbit pAb

CAT: 0855-ES7896-01Size: 50 µLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0855-ES7896-01Size:50 µL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene may increase the risk of getting certain cancers and have been linked to sleep disorders. [provided by RefSeq, Jan 2014]
Description
This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene may increase the risk of getting certain cancers and have been linked to sleep disorders. [provided by RefSeq, Jan 2014],
Product Name Alternative
PER2; KIAA0347; Period circadian protein homolog 2; hPER2; Circadian clock protein PERIOD 2
UniProt
O15055
Swiss Prot
O15055
Reactivity
Human; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human Period Circadian Protein 2 around the phosphorylation site of Ser662. AA range:636-685
Target
Per2
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
120kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
120kD
Fragment
IgG
Subcellular Location
[Isoform 1]: Nucleus . Cytoplasm . Cytoplasm, perinuclear region . Nucleocytoplasmic shuttling is effected by interaction with other circadian core oscillator proteins and/or by phosphorylation. Translocate to the nucleus after phosphorylation by CSNK1D or CSNK1E. Also translocated to the nucleus by CRY1 or CRY2. PML regulates its nuclear localization. .; [Isoform 2]: Nucleus, nucleolus .
Other Product Names
PER2; KIAA0347; Period circadian protein homolog 2; hPER2; Circadian clock protein PERIOD 2
Gene ID (Human)
8864

UniProtKB · O15055

Period circadian protein homolog 2

PER2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O15055
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PER2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
hPER2
EC number
—
Processing
—
Secondary accessions
A2I2P7, Q4ZG49, Q6DT41, Q9UQ45
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationPhosphoproteinUbl conjugation

Coding sequence diversity

Alternative splicing

Biological process

Biological rhythmsTranscriptionTranscription regulation

Cellular component

CytoplasmNucleus

Disease

Disease variant

Domain

Repeat

Related Products

CatalogName
ES7897-01Per2 rabbit pAb
ES6173-01Tau (phospho Ser262) rabbit pAb
ES6258-01FoxO4 (phospho Ser262) rabbit pAb
ES1323-01HDAC4 (phospho Ser632) rabbit pAb
ES5637-01GluR4 (phospho Ser862) rabbit pAb
ES6767-01PKC β (phospho Ser661) rabbit pAb
ES4968-01Daxx (phospho Ser668) rabbit pAb
ES15424-01Rb (phospho Ser612) rabbit pAb
ES14581-01MYPT1 (phospho-Ser668) rabbit pAb
ES17855-01CARD11 (phospho-Ser652) rabbit pAb

Alternative Products

CatalogName
A1223-01Per2 (phospho Ser662) Antibody
CSB-PA217277Phospho-PER2 (Ser662) Antibody
AF4301-BPPhospho-PER2 (Ser662) Peptide
GTR18569993Per2 (Phospho-Ser662) Antibody
GTR18052925-01Per2 (phospho Ser662) rabbit pAb Antibody
E53P01823Per2 phospho-Ser662 Rabbit Polyclonal Antibody
APRab05239-01Per2 (phospho Ser662) Rabbit Polyclonal Antibody
JOT-AP12937-01Per2(Phospho Ser662) Polyclonal Antibody
E44H01248Per2 (phospho Ser662) Polyclonal Antibody
MBS9616383-01Phospho-PER2 (Ser662) Blocking Peptide

Popular Products