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ERI1 rabbit pAb

CAT: 0855-ES7939-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES7939-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Cofactor:Binds 2 magnesium ions per subunit., enzyme regulation:Although it can bind simultaneously with SLBP to the 3'-end of histone mRNA, the presence of SLBP prevents the exonuclease activity., function:RNA exonuclease that binds to the 3'-end of histone mRNAs and probably degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. Also able to degrade the 3'-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi) . Required for 5.8S rRNA 3'-end processing., sequence caution:Translated as Leu., similarity:Contains 1 exonuclease domain., similarity:Contains 1 SAP domain., subunit:Binds with high affinity to the stem-loop structure of replication-dependent histone pre-mRNAs. Requires the 5'-ACCCA-3' sequence present in stem-loop structure. Able to bind other mRNAs. Binds to 40S and 60S ribosomal subunits and to 80S assembled ribosomes. Also binds to 5.8s ribosomal RNA.
Description
Cofactor: Binds 2 magnesium ions per subunit. enzyme regulation: Although it can bind simultaneously with SLBP to the 3'-end of histone mRNA, the presence of SLBP prevents the exonuclease activity. function: RNA exonuclease that binds to the 3'-end of histone mRNAs and probably degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. Also able to degrade the 3'-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi). Required for 5. 8S rRNA 3'-end processing. sequence Caution: Translated as Leu. similarity: Contains 1 exonuclease domain. similarity: Contains 1 SAP domain. subunit: Binds with high affinity to the stem-loop structure of replication-dependent histone pre-mRNAs. Requires the 5'-ACCCA-3' sequence present in stem-loop structure. Able to bind other mRNAs. Binds to 40S and 60S ribosomal subunits and to 80S assembled ribosomes. Also binds to 5. 8s ribosomal RNA.
Product Name Alternative
ERI1; 3'EXO; THEX1; 3'-5' exoribonuclease 1; 3'-5' exonuclease ERI1; Eri-1 homolog; Histone mRNA 3'-end-specific exoribonuclease; Histone mRNA 3'-exonuclease 1; Protein 3'hExo; HEXO
UniProt
Q8IV48
Swiss Prot
Q8IV48
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human ERI1. AA range:261-310
Target
ERI1
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
37kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
37kD
Fragment
IgG
Subcellular Location
Cytoplasm . Nucleus . Nucleus, nucleolus .
Other Product Names
ERI1; 3'EXO; THEX1; 3'-5' exoribonuclease 1; 3'-5' exonuclease ERI1; Eri-1 homolog; Histone mRNA 3'-end-specific exoribonuclease; Histone mRNA 3'-exonuclease 1; Protein 3'hExo; HEXO
Gene ID (Human)
90459

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