Products for Research Use Only
RegisterLogin

PXR rabbit pAb

CAT: 0855-ES7893-01Size: 50 µLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0855-ES7893-01Size:50 µL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized. [provided by RefSeq, Jul 2008]
Description
This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the Cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized. [provided by RefSeq, Jul 2008],
UniProt
O75469
Swiss Prot
O75469
Reactivity
Human; Rat; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human NR1I2. AA range:91-140
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
Molecular Weight
50kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
50kD
Fragment
IgG
Subcellular Location
Nucleus .
Other Product Names
NR1I2; PXR; Nuclear receptor subfamily 1 group I member 2; Orphan nuclear receptor PAR1; Orphan nuclear receptor PXR; Pregnane X receptor; Steroid and xenobiotic receptor; SXR
Gene ID (Human)
8856

Related Products

CatalogName
ELK6436-01Rat PXR (Pregnane X Receptor) ELISA Kit
ELK11857-01Mouse PXR (Pregnane X Receptor) ELISA Kit
ELK3247-01Human PXR (Pregnane X Receptor) ELISA Kit
ES4666-01RAB3IP rabbit pAb
ES20751-01Gab1 Rabbit rabbit pAb
ES20703-01JAK2 Rabbit rabbit pAb
ES20758-01ERK1 Rabbit rabbit pAb
ES20830-01ATG14L Rabbit rabbit pAb
ES20829-01ATG4a Rabbit rabbit pAb
ES20658-01NM23A Rabbit rabbit pAb

Alternative Products

CatalogName
RTR015Rabbit-to-Rabbit Blocking Reagent
AR05252PU-NRabbit IgG Rabbit Protein
AR05110PU-NRabbit IgM Rabbit Protein
NBP1-71681Rabbit Normal Rabbit Serum
OORA00605-100MLRabbit
KA2017Rabbit Rabbit IgG ELISA Kit
MBS9518120-01ATG4c Rabbit Rabbit Polyclonal Antibody
MBS9518118-01ATG4a Rabbit Rabbit Polyclonal Antibody
MBS9512780-01JAK2 Rabbit Rabbit Polyclonal Antibody
MBS9512768-01VEGF Rabbit Rabbit Polyclonal Antibody

Popular Products