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Cbl (phospho Tyr700) rabbit pAb

CAT: 0855-ES7851-01Size: 50 µLDry Ice: NoHazardous: No
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Background
Cbl proto-oncogene (CBL) Homo sapiens This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia, and expansion of CGG repeats in the 5' UTR has been associated with Jacobsen syndrome. Mutations in this gene are also the cause of Noonan syndrome-like disorder. [provided by RefSeq, Jul 2016]
Description
Cbl proto-oncogene (CBL) Homo sapiens This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia, and expansion of CGG repeats in the 5' UTR has been associated with Jacobsen syndrome. Mutations in this gene are also the cause of Noonan syndrome-like disorder. [provided by RefSeq, Jul 2016],
Product Name Alternative
CBL; CBL2; RNF55; E3 ubiquitin-protein ligase CBL; Casitas B-lineage lymphoma proto-oncogene; Proto-oncogene c-Cbl; RING finger protein 55; Signal transduction protein CBL
UniProt
P22681
Swiss Prot
P22681
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human CBL around the phosphorylation site of Tyr700. AA range:666-715
Target
Cbl
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
120kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
120kD
Fragment
IgG
Subcellular Location
Cytoplasm. Cell membrane. Cell projection, cilium . Golgi apparatus . Colocalizes with FGFR2 in lipid rafts at the cell membrane.
Other Product Names
CBL; CBL2; RNF55; E3 ubiquitin-protein ligase CBL; Casitas B-lineage lymphoma proto-oncogene; Proto-oncogene c-Cbl; RING finger protein 55; Signal transduction protein CBL
Gene ID (Human)
867

UniProtKB · P22681

E3 ubiquitin-protein ligase CBL

CBL_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P22681
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CBL
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.3.2.27
Processing
—
Secondary accessions
A3KMP8
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Ligand

CalciumMetal-bindingZinc

Cellular component

Cell membraneCell projectionCytoplasmGolgi apparatusMembrane

Disease

Disease variantProto-oncogene

PTM

PhosphoproteinUbl conjugation

Domain

RepeatZinc-finger

Molecular function

Transferase

Biological process

Ubl conjugation pathway

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